Isolation and idetification of a new aglycone from acid hydrolysis products of saponin in Centella asiatica
10.7501/j.issn.0253-2670.2016.18.002
- Author:
Jia-Qing CAO
1
Author Information
1. School of Functional Food and Wine, Shenyang Pharmaceutical University
- Publication Type:Journal Article
- Keywords:
2α,3β,23-trihydroxyurs-6,12-dien-28-oic acid;
6β-hydroxy asiatic acid;
Acid hydrolysis;
Asiatic acid;
Centella asiatica (L.) Urban;
Centella-6-ene;
Ursane-type aglycone
- From:
Chinese Traditional and Herbal Drugs
2016;47(18):3155-3158
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents of the acid hydrolysis products, in order to find some new aglycones from the hydrolysate of the saponin of Centella asiatica. Methods: The acid hydrolytic product was separated by repeated silica gel, Sephadex LH-20 chromatography. The cytotoxic activities in vitro of some compounds isolated were evaluated. Their structures isolated were identified by analysis of their spectral data of NMR, MS, IR, and UV. Results: Four aglycones, 2α,3β,23-trihydroxyurs-6,12-dien-28-oic acid (1), asiatic acid (2), 6β-hydroxy asiatic acid (3), terminolic acid (4), were isolated from the hydrolysis product. Conclusions: Compound 1, named centella-6-ene, was a new ursane-type aglycone and it showed no cytotoxic activities against the tested cancer cell lines.
