Optimization of preparation of curcumin-catanionic nanoparticles lipid carriers by central composite design-response surface methodology
10.7501/j.issn.0253-2670.2016.19.009
- Author:
Bi-Lin LIU
1
Author Information
1. Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University
- Publication Type:Journal Article
- Keywords:
Catanionic nanoparticles lipid carriers;
Central composite design-response surface methodology;
Curcumin;
Drug loading;
Entrapment efficiency;
Solvent emulsification-evaporation method
- From:
Chinese Traditional and Herbal Drugs
2016;47(19):3401-3406
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize the formulation of curcumin-catanionic nanoparticles lipid carriers (Cur-CNLC) by central composite design-response surface methodology (CCD-RSM). Methods: Cur-CNLC were prepared by film dispersion-ultrasonic emulsifying method. A four factor, five-level central composite design was employed, with the solid lipid quality (X1), liquid lipid quality (X2), lecithin quality (X3), and mixed surfactant concentration (X4) as the independent variables. The dependent variables were the entrapment efficiency (Y1) and drug loading (Y2). The data were simulated using multi-linear equation and second-order polynomial equation, the possibly optimal formulation was predicted by response surface method. Results: The entrapment efficiency, drug loading, average particle size, polydispersity, and Zeta potential of the Cur-CNLCs prepared under the optimized conditions were (94.38 ± 2.67)%, (6.93 ± 0.39)%, (235.9 ± 9.6) nm, 0.272 ± 0.017, and (-28.40 ± 0.35) mV, respectively. The bias between the measured values and the predicted ones is less than 5%. Conclusion: The CCD-RSM is effective and suitable for optimizing the formulation of Cur-CNLC.
