Effect of Shunaoxin Dropping Pill on blood pressure and cardiac protection in spontaneously hypertensive rats
10.7501/j.issn.0253-2670.2016.20.017
- Author:
Hong ZHOU
1
Author Information
1. College of Pharmaceuticals and Biotechnology, Tianjin University
- Publication Type:Journal Article
- Keywords:
Angiotensin II;
Blood pressure;
Cardiac protection;
Nitric oxide synthase;
Shunaoxin Dropping Pill;
Spontaneously hypertensive rats;
Ventricular hypertrophy
- From:
Chinese Traditional and Herbal Drugs
2016;47(20):3662-3667
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the effect of Shunaoxin Dropping Pill (SDP) on blood pressure and cardiac protection in spontaneously hypertensive rats (SHRs). Methods: The SHRs were randomly divided into three groups, model (M) group, SDP group, and valsartan (VL) group. Non-invasive blood pressure instrument was used to measure blood pressure. Serum content of nitric oxide synthase (NOS) and angiotensin II (Ang II) were measured using kits for 6 weeks after ig administration. Doppler echocardiography was used to evaluate left ventricular weight, and HE staining was used to assess aortic and cardiac morphology. Results: The blood pressure of SHRs decreased to minimum 1 h after ig administration of SDP (800 mg/kg). Long-term use of SDP could stabilize blood pressure of SHRs. Serum content of NOS in SDP group was significantly more than that in M group (P < 0.05). The serum content of Ang II in SDP group was significantly less than that in M group (P < 0.05). The left ventricular weight of SDP group was significantly lower than that in M group (P < 0.05). SDP administered group can improve myocardial and aortic morphology abnormalities caused by hypertension. Conclusion: SDP has a certain therapeutic effect on hypertensive with myocardial hypertrophy rats, it can be used as a potential drug on hypertensive disorders associated with cardiac hypertrophy.
