Chemical constituents from Scutellaria barbata
10.7501/j.issn.0253-2670.2016.24.004
- Author:
Guo-Chun YANG
1
Author Information
1. School of Pharmacy, Shenyang Pharmaceutical University
- Publication Type:Journal Article
- Keywords:
5-hydroxy-6,7,3',4'-tetramethoxy- flavone;
6-hydroxyluteolin;
Hispidulin-7-O-β-D-methylgluzcuronide;
Isoscutellarein-8-O-β-D-glucuronide-6″-methyl ester;
Lamiaceae;
Scutellarein-7-O-β-D- glucuronide methyl ester;
Scutellaria barbata D. Don;
Scutellaria Linn.
- From:
Chinese Traditional and Herbal Drugs
2016;47(24):4322-4325
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the constituents in the aerial parts of Scutellaria barbata. Methods: The isolation and purification of the compounds were performed by AB-8 macroporous adsorption resin, silica gel, polyamide and Sephadex LH-20 column chromatography, and their structures were determined on physicochemical characters and spectroscopic data. Results: Fourteen compounds were separated and elucidated as hispidulin-7-O-β-D-methylgluzcuronide (1), apigenin (2), scutellarin (3), scutellarein (4), luteolin (5), scutellarein-7-O-β-D-glucuronide methyl ester (6), isoscutellarein-8-O-β-D-glucuronide-6″-methyl ester (7), apigenin-7-O-β-D-glucuronide-6″-methyl ester (8), 4'-hydroxywogonin (9), 4',5-dihydroxy-3',5',6,7-tetramethoxyflavone (10), isoscutellarein (11), 6-hydroxyluteolin (12), 5-hydroxy-6,7,3',4'-tetramethoxyflavone (13), salvigenin (14). Conclusion: Compound 7 is isolated from Lamiaceae for the first time, compounds 1 and 13 are for the first time isolated from the genus Scutellaria, and compounds 6 and 12 are for the first time obtained from S. barbata.
