1H-NMR-based metabonomics study on toxicity alleviation effect of Bovis Calculus Artificialis, Gypsum Fibrosum, and Borneolum Synthcticum to Realgar (As2S2) in Niuhuang Jiedu Tablet
10.7501/j.issn.0253-2670.2017.01.018
- Author:
Wen-Feng XU
1
Author Information
1. Department of pharmacy, National Center of Gerontology, Beijing Hospital
- Publication Type:Journal Article
- Keywords:
Borneolum Synthcticum;
Bovis Calculus Artificialis;
Gypsum Fibrosum;
Metabonomics;
Niuhuang Jiedu Tablet;
Realgar;
Toxicity alleviation
- From:
Chinese Traditional and Herbal Drugs
2017;48(1):129-135
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the toxicity alleviation effect of Bovis Calculus Artificialis, Gypsum Fibrosum, and Borneolum Synthcticum to Realgar in Niuhuang Jiedu Tablet based on 1H-NMR metabonomics. Methods: Forty-two male Wistar rats were divided into six groups: group A (control group), group B (treated with realgar), group C (treated with Niuhuang Jiedu Tablet), group D (treated with Niuhuang Jiedu Tablet without Bovis Calculus Artificialis), group E (treated with Niuhuang Jiedu Tablet without Gypsum Fibrosum), and group F (treated with Niuhuang Jiedu Tablet without Borneolum Synthcticum). Based on 1H-NMR spectra of urine and serum from rats, PLS-DA was performed to identify different metabolic profiles. Results: The metabolic profiles of group B were different from control group, while the metabolic profiles of all other groups were almost in line with those of control group. Conclusion: The toxicity alleviation effects of Bovis Calculus Artificialis, Gypsum Fibrosum, and Borneolum Synthcticum to Realgar in Niuhuang Jiedu Tablet are not obvious.
