Development of drug toxicity and novel strategy for toxicity of Chinese materia medica based on zebrafish model
10.7501/j.issn.0253-2670.2017.01.002
- Author:
Yun-Ru PENG
1
Author Information
1. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Drug toxicity;
Model organism;
Toxicity assessment of zebrafish model;
Toxicity of Chinese materia medica;
Zebrafish
- From:
Chinese Traditional and Herbal Drugs
2017;48(1):17-30
- CountryChina
- Language:Chinese
-
Abstract:
With the advantages of high throughput activity screening and toxicity evaluation, zebrafish has become popular model organism in pharmaceutical research in recent years. Being integrated advantages both in vivo and in vitro, with high efficiency and low cost, evaluation using zebrafish has become an effective method in quick screening of early safety of compounds on abroad. In past years, studies on toxicity of traditional Chinese medicine (TCM) with zebrafish model have attracted more attention in China. The development in drug toxicity studies based on zebrafish model was reviewed, and novel strategy for toxicity of TCM using zebrafish was suggested in the paper.
