Preparation and in vitro/in vivo evaluation of polydatin solid dispersion
10.7501/j.issn.0253-2670.2017.03.009
- Author:
Wei-Ye CHENG
1
Author Information
1. Anhui Province Key Laboratory of Research and Development of Traditional Chinese Medicine, Anhui University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Bioavailability;
Differential scanning calorimetry;
Dissolution;
Fourier transform infrared spectroscopy;
HPLC;
In vitro dissolution;
Pharmacokinetics;
Polydatin;
Solid dispersion;
Solvent evaporation;
X-ray power diffraction
- From:
Chinese Traditional and Herbal Drugs
2017;48(3):468-473
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Polydatin solid dispersion (PD-SD) was prepared for improving bioavailability. Methods: In this study, PD-SD was prepared by solvent evaporation method with dissolution as index for improving bioavailability. The physicochemical properties of PD-SD were evaluated by Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), X-ray power diffraction (XRD), and scanning electron microscope (SEM). HPLC was employed to determine the plasma concentration of PD-SD with PD crude drug as reference group in rats after oral administration. Results: FT-IR revealed that there was no new chemical bond between drug and carrier. DSC and XRD results indicated that PD in PD-SD was amorphous. SEM results showed that the morphology of PD-SD was close to irregular globular. The AUCs of PD-SD and PD were 328.79 and 139.70 μg·min/mL after oral administration, respectively. Conclusion: PD-SD is prepared by simple technology. PD-SD significantly improved the in vitro dissolution and oral bioavailability of PD in rats.
