Chemical constituents from fruiting bodies of Ganoderma daiqingshanense
10.7501/j.issn.0253-2670.2017.03.004
- Author:
Ning-Ning LAN
1
Author Information
1. College of Horticulture, Hainan University
- Publication Type:Journal Article
- Keywords:
3-O-acetyltohogenol;
3β,21α-serratenediol-3-acetate;
3β,21β-serratenediol-3-acetate;
Acetylcholinesterase inhibitory activities;
Ganoderma daiqingshanense J. D. Zhao;
Ganodermataceae
- From:
Chinese Traditional and Herbal Drugs
2017;48(3):437-442
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents of the fruiting bodies of Ganoderma daiqingshanense. Methods: The constituents were separated by Silica gel and Sephadex LH-20 column chromatography, their structures were elucidated by spectral data analyses, and the acetylcholinesterase inhibitory activity was detected. Results: Twelve compounds were isolated from the fruiting bodies of G. daiqingshanense and identified as 3β,21β-serratenediol-3-acetate (1), 3β,21α-serratenediol-3-acetate (2), 3-O-acetyltohogenol (3), 20 (29)-lupen-3β-ol (4), lucialdehyde A (5), ganoderic acid Y (6), ergosta-7,22E-diene-3-one (7), ergosta-4,6,8 (14),22-tetraene-3-one (8), ergosta-7,22E-diene-3β-ol (9), 5α,8α-epidioxyergosta-6,22E-diene-3β-ol (10), ankylosaurus acid (11), and euphorbia factor L3 (12). Compounds 5, 11, and 12 showed moderate activities against acetylcholinesterase with inhibitory rates of 17.70%, 22.89%, and 21.22%, respectively. Conclusion: All the compounds are obtained from G. daiqingshanense for the first time and serratene triterpenes (compounds 1-3) are found from family Ganodermataceae for the first time. Compounds 5, 11, and 12 have certain inhibitory activities on acetylcholinesterase.
