A Case of Pseudomembranous Colitis Associated with Rifampin.
- Author:
Ji Young PARK
1
;
Joon Seok KIM
;
Sun Jong JEUNG
;
Myung Sook KIM
;
Seok Chan KIM
Author Information
1. Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. cmcksc@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Pseudomembranous Colitis;
Antitubercular agent;
Rifampin
- MeSH:
Aged;
Aged, 80 and over;
Antibiotics, Antitubercular/*adverse effects;
Diarrhea/etiology;
Enterocolitis, Pseudomembranous/*chemically induced;
Humans;
Male;
Rifampin/*adverse effects;
Tuberculosis, Pulmonary/drug therapy
- From:The Korean Journal of Internal Medicine
2004;19(4):261-265
- CountryRepublic of Korea
- Language:English
-
Abstract:
Pseudomembranous colitis is known to develop with long-term antibiotic administration, but antitubercular agents are rarely reported as a cause of this disease. We experienced a case of pseudomembranous colitis associated with rifampin. The patient was twice admitted to our hospital for the management of frequent bloody, mucoid, jelly-like diarrhea and lower abdominal pain that developed after antituberculosis therapy that included rifampin. Sigmoidoscopic appearance of the rectum and sigmoid colon and mucosal biopsy were compatible with pseudomembranous colitis. The antitubercular agents were discontinued and metronidazole was administered orally. The patient's symptoms were resolved within several days. The antituberculosis therapy was changed to isoniazid, ethambutol and pyrazinamide after a second bout of colitis. The patient had no further recurrence of diarrhea and abdominal pain. We report here on a case of pseudomembranous colitis associated with rifampin.
