Optimization of dry granulation prescription and technology of Xiaochuan Granules based on physical characteristics of raw materials in preparations
10.7501/j.issn.0253-2670.2017.04.011
- Author:
En-Li ZHOU
1
Author Information
1. Jiangsu Kanion Pharmaceutical Co., Ltd.
- Publication Type:Journal Article
- Keywords:
Accessories screening;
Dry granulation;
Information entropy;
Physical characteristics;
Xiaochuan Granules
- From:
Chinese Traditional and Herbal Drugs
2017;48(4):681-685
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To utilize powder physical characteristics, optimize prescription of dry granulation process of Xiaochuan Granules (XG). Methods: Filtering of granulation prescription was guided by investigating of powder material physical characteristics such as angle repose, compression degree, water content, etc; With one time forming rate, friability and quality score of granulation process as indexes, L9(34) orthogonal test which based on the evaluation method of information entropy was used to optimize the process parameters in XG dry granulation. Results: The optimum accessory is CD, optimum dry granulation technology parameters was as follows: roll wheel pressure of 7 MPa, roll wheel speed of 10 r/min, and feed speed of 18 r/min. Conclusion: Study of physical property of preparation materials could guide filtering prescription of dry granulation preparation; The prepared granules have high forming rate with moderate hardness and good flowability, and this optimized dry granulation technology is stable and reasonable.
