Chemical constituents in transformation product of Fusarium sacchari from leaves saponin of Panax ginseng
10.7501/j.issn.0253-2670.2017.04.006
- Author:
Dan WANG
1
Author Information
1. Shenyang Second Hospital of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
20(S)-panaxadiol;
20(S)-protopanoxa-diol;
Biotransformation;
Fusarium sacchari;
Ginsenoside F1;
Leaves saponin of Panax ginseng
- From:
Chinese Traditional and Herbal Drugs
2017;48(4):648-652
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents of transformed products by Fusarium sacchari from the leaves saponin of Panax ginseng. Methods: Transformation products separated by the process of silica gel column, compounds were identified and elucidated by spectral and chemical methods. Results: Ten compounds were isolated from transformed products of Fusarium sacchari from the leaves saponin of P. ginseng and identified as 20 (S)-panaxadiol (1), 20 (S)-protopanoxa-diol (2), 20 (R)-protopanoxa-diol (3), 20 (S)-panaxatriol (4), 20 (S)-protopanaxatriol (5), 20 (R)-protopanaxatriol (6), 20 (S)-protopanoxadiol-20-O-β-D-glucopyranose (7), ginsenoside-F1 (8), ginsenoside Rh1 (9), and ginsenoside Rg1 (10). Conclusion: Compounds 1-10 are the compounds of ginsenosides, isolated from transformed products of F. sacchari from the leaves saponin of P. ginseng for the first time. F. sacchari could transform leaves saponin of P. ginseng to rare antitumor saponin, which is a rare active microbial strain with exploitation value.
