Method of quality marker research and quality evaluation of Chinese materia medica based on drug properties and effect characteristics
10.7501/j.issn.0253-2670.2017.06.001
- Author:
Tie-Jun ZHANG
1
Author Information
1. Tianjin Institute of Pharmaceutical Research
- Publication Type:Journal Article
- Keywords:
Biosynthetic approach;
Chinese medicine industry;
Drug property;
Quality marker;
Quality of Chinese materia medica;
Research approach;
Research idea;
Research method
- From:
Chinese Traditional and Herbal Drugs
2017;48(6):1051-1060
- CountryChina
- Language:Chinese
-
Abstract:
The quality of Chinese materia medica (CMM) is the lifeline of Chinese medicine industry. However, many problems are still found in the quality study on CMM, which restricts the healthy development of Chinese medicine industry to a certain extent. Aiming at the problems existing in the quality research on CMM, the research idea, method and approach of quality marker research and quality evaluation of CMM were put forward based on systematic analysis and discussion on the basic properties and clinical features of CMM according to the core concept of quality marker and the combination of research practice, from the perspective of transmission and traceability of quality elements, the relationship between chemical composition and traditional efficacy containing "drug property" and "drug function", composition analysis of endemicity based on pharmacophylogenetic study and biosynthetic approach. Finally, a new integrated mode of CMM quality evaluation and control was established.
