Preliminary study on serum pharmacochemistry of leaves of Acanthopanax senticosus base on UPLC-Q-TOF-MS
10.7501/j.issn.0253-2670.2017.07.008
- Author:
Wen-Feng WEI
1
Author Information
1. Heilongjiang Academy of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Caffeic acid;
Chlorogenic acid;
Leaves of Acanthopanax senticosus (Rupr. et Maxim.) Harms;
Serum pharmacochemistry;
Transitional constituents;
UPLC-Q-TOF-MS/MS
- From:
Chinese Traditional and Herbal Drugs
2017;48(7):1306-1313
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the serum pharmacochemistry of leaves of Acanthopanax senticosus. Methods: Rats were ig administered A. senticosus extracts and then the serum was colleted. Rapid identification of transitional constituents absorbed into blood was carried out by UPLC-Q-TOF-MS/MS. The transitional constituents were identified and speculated by Peakview and MetabolitePilot data processing software using retention time, exact relative molecular mass, and cleavage fragments of MS/MS as indexes. Results: After administration of the leaves of A. Senticosus, 19 transitional constituents absorbed into blood were detected in serum, nine of them were prototype constituents and the other 10 were metabolites. Conclusion: Transitional constituents of the leaves of A. senticosus absorbed into blood are preliminarily identified, which could clarify its pharmacodynamic material basis.
