Lanostane triterpenoids of Ganoderma lucidum and their inhibitory effect on α-glucosidase
10.7501/j.issn.0253-2670.2017.07.002
- Author:
Xin-Min CAO
1
Author Information
1. Department of Pharmacy, Hangzhou Fuyang Hospital of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Ganoderanol A;
Ganoderma lucidum (Leyss. ex Fr.) Karst.;
Lanostane-type;
Methyl ganoderate D;
Triterpenoids;
α-glucosidase
- From:
Chinese Traditional and Herbal Drugs
2017;48(7):1275-1281
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents from the dried fruiting body of Ganoderma lucidum and its activities. Methods: The compounds were isolated and purified from the 95% ethanol extract of G. lucidum by silica gel CC, MPLC, HPLC, and so on. Their structures were identified by extensive spectroscopic analysis. The compounds were evaluated for their inhibitory effects against α-glucosidase compared with those of the positive control acarbose. Results: A total of 11 lanostane triterpenoids were isolated from the 95% ethanol extract of G. lucidum and identified as ganoderanol A (1), ganoderic acid H (2), ganoderic acid AM1 (3), ganoderic acid D (4), methyl ganoderate D (5), ganolucidic acid E (6), 11α-hydroxy-3,7-dioxo-5α-lanosta-8,24 (E)-dien-26-oic acid (7), ganoderenic acid D (8), lucidenic acid A (9), methyl lucidenate F (10), and lucidenic acid B (11). Conclusion: Among them, compound 1 is a new compound. Additionally, compounds 1 and 5 show moderate inhibitory effect on α-glucosidase.
