Advances in β-carboline alkaloids from natural products and their biological activities
10.7501/j.issn.0253-2670.2017.11.032
- Author:
Yu DENG
1
Author Information
1. Chongqing Academy of Animal Sciences
- Publication Type:Journal Article
- Keywords:
Antimalarial;
Antitumor;
Fungi;
Marine organism;
Natural products;
Terrestrial plant;
β-carboline alkaloids
- From:
Chinese Traditional and Herbal Drugs
2017;48(11):2353-2364
- CountryChina
- Language:Chinese
-
Abstract:
β-carboline alkaloids are widely distributed in nature. Their structures are usually simple and thus are easy to synthesized or modified. β-carboline alkaloids exhibit a wide range of biological activities, such as antitumor, antimalarial, cure impotence, treatment for type 2 diabetes, antiviral, antifungal, etc. Since its structural features and good biological activities, pharmaceutical corporations and research institutes have focused on it in a long time, which results in β-carboline alkaloids become a research hotspot in organic synthesis and medicinal chemistry areas, especially some pharmaceutical corporations designed and synthesized many β-carboline alkaloids derivatives with excellent biological activities by high throughput screening and computer aided drug design technologies. This review summarizes the recent progress on β-carboline alkaloids extracted from marine organism, terrestrial plant, and fungi together with their biological activities over the past 20 years.
