Inhibition of annonaceous acetogenins on cell activities of human gastric cancer cells in vitro
10.7501/j.issn.0253-2670.2017.14.015
- Author:
Jian-Bin YE
1
Author Information
1. Biotherapy Institute, School of Biotechnology, Southern Medical University
- Publication Type:Journal Article
- Keywords:
Adhesion;
AGS cells;
Annonaceous acetogenins;
BGC823 cells;
Human gastric cancer cells;
Migration;
MKN45 cell;
SGC7901 cells;
Viability
- From:
Chinese Traditional and Herbal Drugs
2017;48(14):2895-2901
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of annonaceous acetogenins (ACGs) on human gastric cancer cells in vitro. Methods After ACGs were administered to gastric cancer cells in vitro, the cell viability, cell adhesion ability and cell migration ability were assessed by MTT assay, adhesion assay and wound-healing assay, respectively. Results ACGs inhibited the cell viability, adhesion ability and migration ability in a dose-dependent manner in gastric cancer cells. Conclusion ACGs could inhibit cell activities of human gastric cancer cells in viro, and will be developed as a promising anticancer candidate and used in gastric cancer.
