Optimization of matrix prescription of Compound Qingfengteng Cataplasm by orthogonal test method
10.7501/j.issn.0253-2670.2017.16.015
- Author:
Xin-Yuan LIN
1
Author Information
1. Anhui University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Cataplasm;
Compound Qingfengteng;
Matrix prescription;
Orthogonal test;
Penetration enhancers;
Single factor test
- From:
Chinese Traditional and Herbal Drugs
2017;48(16):3347-3352
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize the matrix prescription of Compound Qingfengteng Cataplasm (CQC). Methods: Taking the comprehensive senses as evaluation index, the types and dosage of the matrix were investigated by single factor. Further combined with the initial viscosity and holding viscosity index to optimize the matrix prescription of CQC by orthogonal test, and in vitro transdermal absorption experiments were carried out by Franz diffusion pool method to screen penetration enhancers. Results: The optimal formulation of CQC was as follows: 2.5 g of NP-700, 11 g of glycerin, 0.08 g of glycine aluminum, 0.08 g of tartaric acid, 0.8 g of PVP K90, 0.5 g of PVPP, 20 g of water, and 4.2 g of dry extract. 3% nitrile as a penetration agent could enhance penetration action. Conclusion: The preferred matrix prescription is practicable; CQC adhesion is moderate, no residue, paste traits, skin followability are good.
