Effect of TY501 on carbon tetrachloride-induced liver fibrosis in mice
10.7501/j.issn.0253-2670.2017.17.016
- Author:
Shi-Chao ZHU
1
Author Information
1. School of Pharmacy, Tianjin Medical University
- Publication Type:Journal Article
- Keywords:
Carbon tetrachloride;
Glycyrrhetic acid derivatives;
Hydroxyproline;
Liver fibrosis;
Transforming growth factor-β1;
TY501
- From:
Chinese Traditional and Herbal Drugs
2017;48(17):3554-3559
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the protective effects of glycyrrhetic acid derivatives (TY501) on carbon tetrachloride-induced liver fibrosis in mice. Methods The mice liver fibrosis was established by classical CCl4, and TY501 was given in three kinds of dosage (45, 15, and 5 mg/kg), with colchicine serving as control. After 30 d treatment, the liver function, fibrosis and the levels of Hyp and TGF-β1 were detected. Moreover, the histopathological changes were detected by HE and Masson staining. Results Compared with model group, the levels of ALT, AST, ALP, ALB, HA, LN, PCIII, CIV, Hyp, and TGF-β1 were all decreased, with high-dose group being the most significant (P < 0.05, 0.01). Histopathological examination showed that liver fibrosis of those mice treated with TY501 was improved to some extent. Conclusion TY501 can significantly protect carbon tetrachloride-induced hepatic fibrosis.
