Two new sesquiterpenoids from leaves of Magnolia grandiflora
10.7501/j.issn.0253-2670.2017.17.002
- Author:
Lin-Fen DING
1
Author Information
1. School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University
- Publication Type:Journal Article
- Keywords:
Compressanolide;
Magnogranol A;
Magnogranol B;
Magnolia grandiflora L.;
Sesquiterpenoids;
Α-santonin
- From:
Chinese Traditional and Herbal Drugs
2017;48(17):3463-3468
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the chemical constituents from the leaves of Magnolia grandiflora. Methods The chemical constituents were isolated and purified by various column chromatographic techniques, including silica gel and Sephadex LH-20, and the structures were identified by spectroscopic analyses. Results Eight sesquiterpenoids were isolated from 70% aq. acetone extract of M. grandiflora and the structures were identified as 12,13-diacetoxy-eudesma-4α,6α,11-triol (1), 12,13-diacetoxy-5αH-guaia-1 (10)-en-4α,6α,11-triol (2), 11,13-dehydrocompressanolide (3), compressanolide (4), α-santonin (5), 1β-hydroxyl-11βH-eudesma-3- en-12,6α-olide (6), β-dictyopterol (7), and 12α-methoxy-germacran-1(10), 4,11(13)-trien-12,6α-acetal (8). Conclusion Compounds 1 and 2 are new compounds named as magnogranol A and B, and compounds 4-8 are isolated from this plant for the first time.
