Chemical constituents from flower buds of Lonicera japonica
10.7501/j.issn.0253-2670.2017.18.004
- Author:
Fu-Yong NI
1
Author Information
1. The Key Laboratory for the New Technique Research of TCM Extraction and Purification, State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process, Jiangsu Kanion Pharmaceutical Co., Ltd.
- Publication Type:Journal Article
- Keywords:
3',4',7-trihydroxy-3,5- dimethoxyflavone;
Flower buds of Lonicera japonica;
Isorhamnetin;
Kaemnpferol-3-O-β-D-glucopyranoside;
Vanillic acid
- From:
Chinese Traditional and Herbal Drugs
2017;48(18):3689-3692
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the chemical constituents of the flower buds of Lonicera japonica. Methods The chemical constituents were isolated by repeated silica gel chromatography, Sephadex LH-20, medium pressure column chromatography and preparative HPLC, and their structures were elucidated by spectroscopic analyses and comparison of MS, 1H-NMR and 13C-NMR data with those reported in literature. Results Twelve compounds from the EtOAc fraction of L. japonica included p-hydroxybenzoic acid (1), vanillic acid (2), quercetin-3-O-α-L-rhamnopyranoside (3), kaemnpferol-3-O-β-D-glucopyranoside (4), 3',4',7-trihydroxy- 3,5-dimethoxyflavone (5), isorhamnetin (6), hyperoside (7), quercetin-7-O-β-D-glucopyranoside (8), secologanic acid (9), vogeloside (10), 5-O-caffeoylquinic acidmethylester (11) and stigmasterol (12). Conclusion Compound 5 is obtained from the plant in Lonicera Linn. for the first time; Compounds 1-4, 6, 11 and 12 are obtained from this plants for the first time.
