Explore of synthesis method of different configuration pseudo-ginsenoside Rg2, pseudo-ginsenoside Rh1, and pseudo-PPT
10.7501/j.issn.0253-2670.2017.20.016
- Author:
Hong-Da DING
1
Author Information
1. Department of Chemistry, Jilin University
- Publication Type:Journal Article
- Keywords:
Pseudo-ginsenoside Rg2;
Pseudo-ginsenoside Rh1;
Pseudo-PPT;
Rare ginsenoside;
Synthesis
- From:
Chinese Traditional and Herbal Drugs
2017;48(20):4224-4228
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore an efficient preparation method of pseudo-ginsenoside Rg2, pseudo-ginsenoside Rh1, and pseudo-PPT, as to provide theoretical basis for the preparation of pseudo-ginsenosides and pseudo-PPT. Methods Ginsenosides Re, Rh1, and PPT as raw material, via a simple three-step called acetylation, elimination-addition and saponification achieve the preparation of 20 (E/Z)-pseudo-ginsenoside Rg2, 20 (E/Z)-pseudo-ginsenoside Rh1, and 20 (E/Z)-pseudo-PPT. The detailed structure elucidation of the compounds were obtained by NMR, HR-ESI-MS, and IR. Results The production rates of 20 (E/Z)-pseudo-ginsenoside Rg2, 20 (E/Z)-pseudo-ginsenoside Rh1, and 20 (E/Z)-pseudo-PPT were 41%/13%, 43%/11%, and 56%/15%, respectively. Among them, 20 (Z)-pseudo-PPT was identified as new triterpenoid. Conclusion The method through the price relatively cheap and easy gain reactants ginsenoside Re, ginsenoside Rh1, and PPT prepared active better pseudo-ginsenoside Rg2, pseudo-ginsenoside Rh1, and pseudo-PPT, the method for the preparation of other types of pseudo-ginsenoside provides a new train of thought. At the same time, the method is simple and the yield is high.
