Chemical constituents of stems and leaves of Clausena hainanensis
10.7501/j.issn.0253-2670.2017.21.004
- Author:
Yan-Lei MA
1
Author Information
1. School of Pharmacy, Fujian University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
3-formylcarbazole;
Alkaloids;
Clausena haianensis Huang ex Xing;
Coumaric acid;
Coumarin;
Isocoumarin;
Isololiolide;
Phenolic acid;
Sesquiterpene
- From:
Chinese Traditional and Herbal Drugs
2017;48(21):4388-4393
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the chemical constituents of the stems and leaves of Clausena hainanensis. Methods The chemical constituents of C. hainanensis were separated and purified by silica gel, ODS, Sephadex LH-20 gel column chromatographies, and preparative HPLC. Their structures were identified by physicochemical properties, spectroscopic analysis, as well as comparisons with the data reported in literature. Results Eighteen compounds were isolated from the 90% ethanol extract of the stems and leaves of C. hainanensis, which were identified as mukonine (1), methyl carbazole-3-carboxylate (2), lansine (3), murrayanine (4), 3-formylcarbazole (5), 3-formyl-6-methoxycarbazole (6), lansamide 4 (7), 4-methoxy-N-methyl-2-quinolone (8), (E)-N- (4-methoxyphenethyl)-2-methylbut-2-enamide (9), (E)-N-methyl cinnamon amide (10), N-(2-hydroxy-2-phenylethyl) cinnamamide (11), N-benzoyltyramine (12), aurantiamide (13), N-methyl-2-pyrolidinone (14), coumaric acid (15), 6,8-dimethoxy-4,5-dimethyl-3- methyleneisochromanl-one (16), 8-methoxypsoralen (17), and isololiolide (18). Conclusion This is the first time reporting the chemical constituents from C. hainanensis, all compounds are isolated from C. hainanensis for the first time, and compounds 12-16 are isolated from the genus Clausena for the first time.
