The immunohistochemical study on Ki-67 Expression in epithelial ovarian carcinomas.
- Author:
Chang Min PARK
1
;
Song Yee HAN
;
Insun KIM
;
Hyun Chul KIM
;
Jae Seong KANG
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Korea University, Seoul, Korea. jskang@kumc.or.kr
- Publication Type:Original Article
- Keywords:
Ki-67 antigen;
Immunohistochemistry;
Ovary;
Carcinoma
- MeSH:
Antibodies, Antinuclear;
Antibodies, Monoclonal;
Carcinoma, Endometrioid;
Cystadenocarcinoma, Mucinous;
Cystadenocarcinoma, Serous;
Female;
Gynecology;
Humans;
Immunohistochemistry;
Ki-67 Antigen;
Korea;
Ovary
- From:Korean Journal of Obstetrics and Gynecology
2008;51(11):1288-1294
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The study was to evaluate the biological significance of Ki-67 expression in common epithelial ovarian carcinomas. We investigated the correlation between Ki-67 expression and clinicopathological parameters. METHODS: One hundred patients with epithelial ovarian carcinomas stage I-IV treated at Department of Obstertrics and Gynecology, Korea University Hospital from January 1994 to December 2004 were used as study group. We determined expression of Ki-67 by immunohistochemistry using MIB-1 monoclonal antibody reactivity. RESULTS: Ki-67 overexpression was higher in high stage (III-IV) than low stage (I-II) (P<0.013). Ki-67 overexpression was higher in serous cystadenocarcinoma (76.3%) than mucinous cystadenocarcinoma (53.6%), endometrioid carcinoma (54.5%) and clear cell carcinoma (58.3%) but it was not statistically significant (P<0.191). Ki-67 expression was higher in high grade but it was not statistically significant (P<0.096). Ki-67 overexpression was not correlated with serum CA-125 level (P<0.172). Overall survival revealed significant survival difference between patients whose tumor showed Ki-67 overexpressions compared with remaining patients. CONCLUSIONS: Ki-67 overexpressions was a poor prognostic indicator in epithelial ovarian carcinomas.
