Advances in studies on flavonoids regulating autophagy in tumor cell lines
10.7501/j.issn.0253-2670.2017.24.030
- VernacularTitle: 黄酮类化合物调控肿瘤细胞自噬的研究进展
- Author:
Hong ZHANG
1
Author Information
1. Department of Traditional Chinese Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Apoptosis;
Autophagy;
Cytotoxic effect;
Flavonoids;
Tumor cell
- From:
Chinese Traditional and Herbal Drugs
2017;48(24):5252-5262
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is an evolutionary conserved method in cell self-degradation and metabolism progress. Generally speaking, autophagy contains the steps of phagophore devouring none-essential or damaged organelles, lysosome-mediated degradation and reusing of contents in autophagosome. Autophagy plays a significant role in cellular biosynthesis, nutritional and metabolic balance, stress responses and cell survival. Regulating autophagy can induce multiple cascade reactions, which could be a kind of promising tumor therapy. Different flavonoids could induce different roles of autophagy, when they act on different tumor cell lines. Flavonoids can induce non-apoptosis or non-typical apoptosis related inhibitory autophagy to suppress tumor cells proliferation directly, and induce apoptosis or other lethal pathways after induction of autophagy to indirectly inhibit tumor cells proliferation. Flavonoids can also suppress protective autophagy to strengthen other lethal pathways, but sometimes induce protective autophagy which would weaken the cytotoxic effect. This paper reviews the advances in studies on flavonoids regulating autophagy in the last 10 years, in order to provide reference for the further study on the regulation of autophagy by traditional Chinese Medicine.
