Research progress on intestinal immunoregulation and mechanism of Sijunzi Decoction polysaccharide
10.7501/j.issn.0253-2670.2018.02.030
- Author:
Bei-Bei GAO
1
Author Information
1. School of Pharmacy, Shanghai Jiao Tong University
- Publication Type:Journal Article
- Keywords:
Intestinal epithelial cells;
Intestinal flora;
Intestinal immunoregulation;
Intestinal intraepithelial lymphocytes;
Mesenteric lymph nodes;
Peyer’s patch;
Sijunzi Decoction polysaccharide
- From:
Chinese Traditional and Herbal Drugs
2018;49(2):462-467
- CountryChina
- Language:Chinese
-
Abstract:
Sijunzi Decoction polysaccharide (SJZDP) is the active component contributing to the function of intestinal immunoregulation, which is the highest content in Sijunzi Decoction. SJZDP can activate immunological response in peyer’s patch, mesenteric lymph nodes, intestinal epithelial cells and intestinal intraepithelial lymphocytes, but the mechanism is unknown. The reported mechanisms of SJZDP’s intestinal immunoregulation activity are related to its regulation of intestinal flora and polyamine signaling pathway. This review is to give a comprehensive summary of information regarding the intestinal immunoregulation of SJZDP and mechanism to help us take the action for reasonable clinical utilization and further researches.
