Analysis on chemical components in rat lung tissue after oral administration of Qinbai Qingfei Concentrated Pellets based on UPLC-Q-TOF-MS
10.7501/j.issn.0253-2670.2018.05.020
- Author:
Wen-Feng WEI
1
Author Information
1. Heilongjiang Academy of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Lung tissue;
Metabolites;
Mycoplasma pneumonia;
Qinbai Qingfei Concentrated Pellets;
UPLC-Q-TOF-MS
- From:
Chinese Traditional and Herbal Drugs
2018;49(5):1115-1122
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To qualitative analze the chemical components in rat lung tissues after oral administration Qinbai Qingfei Concentrated Pellets (QQCP). Methods: The rat lung tissues were collected and analyzed by UPLC-Q-TOF-MS after ig administration of QQCP. The chemical components in control and dose groups were identified and speculated by Peakview and Metabolite Pilot data processing software using retention time, exact relative molecular mass, and cleavage fragments of MS/MS as indexes. Results: A total of 25 compounds were identified, including 17 prototypes and eight metabolites. Conclusion: The chemical constituents in the rat lung tissues were identified after oral administration of QQCP based on UPLC-Q-TOF-MS, which will contribute to elucidate the effects of potential pharmacodynamic material basis of QQCP on mycoplasma pneumoniae.
