Preparation and quality evaluation of self-emulsifying drug delivery system of total saponins of Sanguisorba officinalis
10.7501/j.issn.0253-2670.2018.06.013
- Author:
Ya ZOU
1
Author Information
1. School of Pharmacy, Zunyi Medical University
- Publication Type:Journal Article
- Keywords:
Bulk drug;
In vitro release;
Self-emulsifying drug delivery system;
Solubility;
Total saponins of Sanguisorba officinalis
- From:
Chinese Traditional and Herbal Drugs
2018;49(6):1317-1323
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize the formulation of the self-emulsifying drug delivery system of total saponins of Sanguisorba officinalis and evaluate its characteristics. Methods: The formulation and its proportion of the self-emulsifying drug delivery system of total saponins of S. officinalis were optimized based on the solubility tests, formula compatibility, microemulsion area in the ternary phase diagram and D-optimal mixing experiment design. The dosage of oil phase, surfactant and co-surfactant were investigated by drug loading, particle size, and polydispersity index. The appearance, particle size, polydispersity index, Zeta potential, and in vitro release of preparation were finally evaluated. Results: The ratio of oil phase, surfactant, and co-surfactant was 0.25: 0.45:0.30. The drug loading was 23.93 mg/g, the average particle size was (207.92 ± 2.13) nm and the zeta potential was (38.84 ± 0.18) mV. The release of SEDDS was superior to the bulk drug apparently. Conclusion: The self-emulsifying drug delivery system of total saponins of S. officinalis was established. The technology was feasible and the quality was stable.
