Study on metabolic pathways of salidroside in rats
10.7501/j.issn.0253-2670.2018.07.018
- Author:
Yu ZHOU
1
Author Information
1. Yantai University
- Publication Type:Journal Article
- Keywords:
Acetylation;
Glucuronidation;
Metabolic pathway;
Metabolites;
Methylation;
Salidroside;
Sulfation;
UPLC-Q-TOF-MS
- From:
Chinese Traditional and Herbal Drugs
2018;49(7):1603-1611
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the metabolic pathways of salidroside when gavaged to rats, and to identify its in vivo metabolites. Methods: A UPLC-Q-TOF-MS method was established and applied to identify the metabolites of salidroside in bile, urine, feces, and plasma samples after ig administration of salidroside 200 mg/kg to rats. Results: A total of 20 metabolites were characterized in rats. The dominant metabolic pathways of salidroside include glucuronidation, acetylation, sulfation, and methylation. Conclusion: Salidroside undergoes extensive phases I and II metabolism in rats. The main excretion path is the phase II conjugated metabolites via urine, feces, and bile. The parent drug of salidroside is the main exposure material in plasma.
