Chemical constituents from Euphorbia helioscopia
10.7501/j.issn.0253-2670.2018.07.006
- Author:
You-Mu QIN
1
Author Information
1. Department of Natural Medicinal Chemistry, China Pharmaceutical University
- Publication Type:Journal Article
- Keywords:
3, 3'-di-O-methylellagic acid;
Bre-vifolin;
Euphorbia helioscopia L.;
Flavonoids;
Helioscopinolide E;
Phenolics;
Terpenoids
- From:
Chinese Traditional and Herbal Drugs
2018;49(7):1520-1524
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the chemical constituents from Euphorbia helioscopia. Methods: The compounds were isolated and purified using macroporous resin, silica gel colimu, ODS, MCI gel and Sephadex LH-20, and their structures were elucidated on the basis of spectral data and physicochemical properties. Results: Sixteen compounds were isolated from 95% ethyl alcohol extract from the whole arial of E. helioscopia and identified as four terpenoides: helioscopinolide E (1), ent-kaurane-3-oxo-16β-17-diol (2), oleanolic acid (3), betulinic acid (4); six phenolics: benzoic acid (5), ethyl gallate (6), 3, 3', 4, 4'-tetrahydroxy diphenyl (7), brevifolin (8), 6-hydroxy-7, 8-methylenedioxy coumarin (9), 3, 3'-di-O-methylellagic acid (10); and five phenolics: apigenin (11), chrysoeriol (12), hyperin (13), naringenin-7-O-β-D-glucoside (14), cannabisci-trin (15), and 3β-hydroxy-cholesta-5-ene (16). Conclusion: Compounds 7-10 and 12 are isolated from this genus for the first time. Compounds 2-5 and 14-15 are isolated from this plant for the first time.
