Chemical constituents from Isodon coetsa distributed in Guizhou
10.7501/j.issn.0253-2670.2018.13.004
- Author:
Jiang-Hai YE
1
Author Information
1. Guiyang University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Emodin;
Formononetin;
Isodon coetsa (Buch. -Ham. ex D. Don) Hara.;
Maslinic acid;
Oleanane;
Sterol;
Ursanes
- From:
Chinese Traditional and Herbal Drugs
2018;49(13):2972-2977
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate chemical constituents from Isodon coetsa distributed in Guizhou. Methods: Chemical constituents were isolated and purified by chromatography with silica gel, Sephadex LH-20, and semi-preparative HPLC, and their structures were identified by analysis of spectroscopic evidences and physicochemical properties as well as relevant references. Results: A total of 19 compounds were isolated from plant material extracted with 95% aqueous methanol, which were elucidated as β-sitosterol (1), stigmasterol (2), β-daucosterol (3), methyl linolenat (4), 9,12-octadecadienoic acid-2-hydroxy-1,3-propanedinyl ester (5), ursolic acid (6), oleanoic acid (7), 3β-hydroxy-urs-20-en-28-oic acid (8), betulinic acid (9), kurarinone (10), maslinic acid (11), 2α-hydroxy ursolic acid (12), 2α,3α-dihydroxy-urs-12-en-28-oic acid (13), 2α,3α,24-trihydrxyolean-12-en-28-oic acid (14), 2α,3β,24- trihydroxyolean-12-en-28-oic acid (15), formononetin (16), emodin (17), uracil (18), and sucrose (19). Conclusion: Compounds 2, 4, 5, 9, 11, 13-19 are isolated from this plant for first time, and compounds 11, 17, 19 are isolated from the genus of Isodon for the first time.
