Research progress on pharmacological effects of dihydromyricetin and its interactions with drugs
10.7501/j.issn.0253-2670.2018.14.030
- Author:
Hai-Yun ZHOU
1
Author Information
1. Department of Pharmacy, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology
- Publication Type:Journal Article
- Keywords:
Antitumor activity;
Chemotherapeutics;
Dihydromyricelin;
Drug interaction;
Neuroprotective effect
- From:
Chinese Traditional and Herbal Drugs
2018;49(14):3411-3418
- CountryChina
- Language:Chinese
-
Abstract:
Dihydromyricetin (DMY) is the main flavonoid compound in Ampelopsis grossedentata. It is popular for various biological and pharmacological activities including antiflammatory, antibacterial, antitumor, regulating blood fat, hypolipidemic, and protecting liver function. Recently studies have suggested that DMY works as neuroprotective molecular, ameliorating neurological abnormal symptoms in the Alzheimer’s disease, Parkinson’s disease, alcohol addiction, major depression disorder and so on. This paper reviewed various pharmacological effects of DMY and analyzed detailedly its interactions with the neuropsychiatric drugs and chemotherapeutics in the metabolism and pharmacodynamics perspectives in the last decade. We further elucidate the role of DMY in the combined medication, aiming to provide scientific reference for its potential in clinic.
