Pharmacological mechanism of main ingredients of Guanxinning Injection treating cardiovascular diseases by computer simulation study
10.7501/j.issn.0253-2670.2018.14.023
- Author:
Bo-Long WANG
1
Author Information
1. School of Chemical and Biological Engineering, Yichun University
- Publication Type:Journal Article
- Keywords:
Cardiovascular diseases;
Computer simulation study;
Danshensu;
Guanxinning Injection;
Network pharmacology;
Pathways enrichment;
Protein-protein interaction;
Protocatechuic aldehyde;
Rosmarinic acid;
Salvianolic acid B;
Tanshinone IIA
- From:
Chinese Traditional and Herbal Drugs
2018;49(14):3357-3368
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study network pharmacology mechanism of main ingredients of Guanxinning Injection treating cardiovascular diseases by computer simulation. Methods: Danshensu, salvianolic acid B, protocatechuic aldehyde, rosmarinic acid, tanshinone IIA, lithospermic acid, ferulic acid, senkyuno lide I, ligustrazine, butylphthalide, and ligustilide from Guanxinning Injection were used to predict and screen the targets by reverse molecular docking technology, and were used to study pharmacological mechanism of main ingredients of Guanxinning Injection treating cardiovascular diseases relying on protein-protein interaction network, GO biological processes enrichment, and KEGG signaling pathways enrichment. Results: There were total 11 active ingredients acting INS, Akt1, TNF, MAPK1, ESR1, F2, SERPINE1, and 142 cardiovascular diseases related targets in Guanxinning Injection. These targets were mainly involved in steroid hormone mediated signaling pathway, glutathione metabolic process, positive regulation of smooth muscle cell proliferation and other biological processes, and regulation of coagulation, inflammation and immune, endocrine, and 20 relevant pathways. Conclusion: Guanxinning Injection participated in the treatment of the cardiovascular diseases by anti-inflammatory, anti-oxidant, anticoagulation, promoting fibrinolysis, regulating hormones, and maintaining cardiovascular homeostasis.
