Chemical structures of alkaloids with hypoglycemic activity and their hypoglycemic mechanisms
10.7501/j.issn.0253-2670.2018.15.032
- Author:
Yu-Hao ZHANG
1
Author Information
1. College of Eco-Environmental Engineering, Qinghai University
- Publication Type:Journal Article
- Keywords:
Alkaloids;
Drug development;
Hypoglycemic activity;
Mechanism of action;
Structure-activity relationship
- From:
Chinese Traditional and Herbal Drugs
2018;49(15):3692-3702
- CountryChina
- Language:Chinese
-
Abstract:
Alkaloids are a class of secondary metabolites with many structural types and significant biological activities in natural organisms. As one of the most important active ingredients in medicinal plants, they are characterized by containing nitrogen atoms in chemical structures, most of them have complex cyclic structures, possessing antitumor, antibacterial, antiviral activities, and so on. This review summarizes the structural types of hypoglycemic alkaloids and their mechanisms, which will provide new insights and references for the research on alkaloid hypoglycemic agents discovery, pharmacology, and structure-activity relationship.
