Discussion and consideration on safety of Sophorae Tonkinensis Radix et Rhizoma and its rational use
10.7501/j.issn.0253-2670.2018.17.029
- Author:
An-Zheng NIE
1
Author Information
1. The First Affiliated Hospital of Zhengzhou University
- Publication Type:Journal Article
- Keywords:
Coexisting of efficacy and poison;
Matrine;
Oxymatrine;
Oxysophocarpine;
Rational use of drugs;
Security issues;
Sophocarpine;
Sophorae Tonkinensis Radix et Rhizoma;
Toxic reaction
- From:
Chinese Traditional and Herbal Drugs
2018;49(17):4152-4161
- CountryChina
- Language:Chinese
-
Abstract:
Sophorae Tonkinensis Radix et Rhizoma is known as the important drug for treating sore throat and is widely used in clinic. Because of the coexisting of its efficacy and poison, Sophorae Tonkinensis Radix et Rhizoma often leads to a series of safety problems in the clinical application process. In this study, we attempt to analyze the ultimate cause of the toxicity of Sophorae Tonkinensis Radix et Rhizoma by reviewing nearly 20 years of literature, discuss the substance of its efficacy/toxicity from the point of view of chemical composition, and put forward exploratory thinking on its clinical rational application.
