A new macamide from Lepidium meyenii cultivated in Lijiang
10.7501/j.issn.0253-2670.2018.19.004
- VernacularTitle: 丽江产玛咖中的1个新玛咖酰胺
- Author:
Wen-Xing LIU
1
Author Information
1. School of Chemistry and Environment, Yunnan Minzu University
- Publication Type:Journal Article
- Keywords:
Cytotoxic activity;
Lepidium meyenii Walp.;
Macalepidiumide A;
Macamides;
N-(3,4-dimethoxybenzyl) hexadec-9Z-enamide
- From:
Chinese Traditional and Herbal Drugs
2018;49(19):4491-4493
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the chemical constituents of the dried roots of Lepidium meyenii cultivated in Lijiang. Methods The samples were extracted by 90% alcohol, and then isolated by silica column, MCI, and HPLC. The structures of the isolated compounds were elucidated by NMR techniques including 2D NMR such as HSQC, HMBC, and COSY. The cytotoxic activity of the new compound against five cell lines (NB4, A549, PC3, SHSY5Y, and MCF7) was evaluated by MTT methods. Results Three macamides were isolated and identified as N-(3,4-dimethoxybenzyl) hexadec-9Z-enamide (1), N-benzyl-13-oxo-9E,11E-octadecadienamide (2) and N-(3,4-dimethoxybenzyl)-hexadecanamide (3) from this plant. Conclusion Compound 1 is a new compound named macalepidiumide A and shows no significant cytotoxic activity.
