Clinical Experiences Treating Edifenphos and Iprobenfos Intoxication Patients.
- Author:
Sun pyo KIM
1
;
Kyung hoon SUN
;
Dae hyuk CHOO
;
Soo hyung CHO
Author Information
1. Department of Emergency Medicine, College of Medicine, Chosun University, Gwangju, Korea. chosooh@naver.com
- Publication Type:Case Report
- Keywords:
Fungicides;
Edifenphos;
Iprobenfos
- MeSH:
Acetylcholinesterase;
Atropine;
Cell Wall;
Chitin Synthase;
Defecation;
Gastrointestinal Motility;
Humans;
Insecticides;
Organothiophosphorus Compounds;
Pralidoxime Compounds;
Salivation;
Urination;
Vomiting
- From:Journal of the Korean Society of Emergency Medicine
2012;23(1):149-153
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Organophosphate fungicides include edifenphos, iprobenfos and tolclofos-methyl. Edifenphos inhibits cell wall synthesis by reduction in chitin synthase activity and inhibits the action of acetylcholinesterase. Thus, exposure to this chemical results in excessive salivation, lacrimation, urination, defecation, gastrointestinal motility and emesis symptoms, just like other organophosphate insecticides. Although edifenphos is an organophosphate fungicide, it is the only agricultural chemical which inhibits the action of pralidoxime and atropine, an activity which in turn, inhibits treatment. Thus, we have to treat these cases as soon as possible with atropine and pralidoxime, using the same approach as used for exposure to other organophosphate insecticides. In this report we evaluate the results of treatment of 4 patients who were intoxicated by fungicides (3 cases with edifenphos and 1 case with iprobenfos).
