Secondary metabolites from marine fungus Penicillium sp. SCS-KFD16
10.7501/j.issn.0253-2670.2018.21.012
- Author:
Fan-Dong KONG
1
Author Information
1. Key Laboratory of Tropical Crops Biology and Genetic Resources Utility, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences
- Publication Type:Journal Article
- Keywords:
2-(4-hydroxy-2-methoxybenzyl)-5-methoxyphenol;
4-(2-hydroxyethyl) phenol;
Marine fungus;
Penicillide;
Penicillium sp.;
Penicinol;
Secondary metabolites
- From:
Chinese Traditional and Herbal Drugs
2018;49(21):5029-5033
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the secondary metabolites of the marine fungus Penicillium sp. SCS-KFD16. Methods The metabolites were isolated and purified by silica gel, ODS column, and preparative HPLC methods. The structures of the compounds were identified by MS and NMR spectral data analysis. The DPPH radical scavenging, acetylcholinesterase, and α-glucosidase inhibitory activities of compounds were evaluated by DPPH method, Ellman colorimetric method, and PNPG method, respectively. Results Six compounds were isolated from the EtOAc extract of the fermentation broth of the marine fungus Penicillium sp. SCS-KFD16, and they were identified as 2-(4-hydroxy-2-methoxybenzyl)-5-methoxyphenol (1), penicillide (2), bioxanthracene 2 (3), 6-ethyl-2,4-dihydroxy-3-methylbenzaldehyde (4),4-(2-hydroxyethyl) phenol (5), and 2-(4-hydroxyphenethyl) acetate (6), respectively. Conclusion Compound 1 is a new compound named penicinol. Compounds 2-6 show DPPH radical scavenging activity and compound 4 exhibits inhibitory activity against α-glucosidase with an IC50 value of 24.4 μmol/L.
