Research progress on metabolism and toxicology of hepatotoxic components in common Chinese materia medica
10.7501/j.issn.0253-2670.2018.22.031
- Author:
Kai ZHANG
1
Author Information
1. Department of Pharmacy, Fuyang People’s Hospital
- Publication Type:Journal Article
- Keywords:
Chinese materia medica;
Hepatotoxicity;
Metabolism;
Toxic ingredient;
Toxicology
- From:
Chinese Traditional and Herbal Drugs
2018;49(22):5435-5447
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, with the steady development of the medicine and health industry in China, Chinese medicine has gradually been recognised and trusted by people around the world, its application amount has being increased in clinic and health care. The worth of its research is also becoming more and more prominent. However, the toxicity and side effects of Chinese materia medica (CMM) have aroused widespread attention, the increasing number of patients with liver function damage has occurred. Thereby, it is urgent to further analyse and study the mechanism of liver toxicity of CMM to ensure the clinical safety and efficacy of common CMM. Based on the latest literatures about hepatotoxicity of common CMM in recent years, the present study analyzed the major mechanism of hepatotoxicity of CMM from the perspective of metabolism and toxicology, in order to provide a novel approach for hepatotoxicity investigation of CMM, and offer the useful reference for the rational application of CMM in clinic.
