Whole-ingredient identification and primary grade evaluation of Niuhuang Qingwei Pills based on reference drug
10.7501/j.issn.0253-2670.2018.22.015
- Author:
Li-Xing NIE
1
Author Information
1. National Institutes for Food and Drug Control
- Publication Type:Journal Article
- Keywords:
Aurantii Immaturus Fructus;
Borneolum Syntheticum;
Bovis Calculus Artifactus;
Chrysanthemi Flos;
Forsythiae Fructus;
Gardeniae Fructus;
Glycyrrhizae Radix et Rhizoma;
Grade evaluation;
Gypsum Fibrosum;
Menthae Haplocalycis Herba;
Microscopic characteristics;
Niuhuang Qingwei Pills;
Ophiopogonis Radix;
Pharbitidis Semen;
Phellodendrl Chinensis Cortex;
Platycodonis Radix;
Reference drug;
Rhei Radix et Rhizoma;
Scrophulariae Radix;
Scutellariae Radix;
Sennae Folium;
Whole-ingredient identification
- From:
Chinese Traditional and Herbal Drugs
2018;49(22):5320-5327
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify whole ingredients in Niuhuang Qingwei Pills (NQP) and give primary grade evaluation of NQP. Methods Firstly, microscopic characteristics specified by the statutory standard of NQP were summarized. Then new microscopic identification methods were established for Sennae Folium and Gypsum Fibrosum while new thin layer chromatography (TLC) identification methods were established for Bovis Calculus Artifactus, Borneolum Syntheticum, and Rhei Radix et Rhizoma. In addition, microscopic identification method for Menthae Haplocalycis Herba was improved. In this way, whole-ingredient identification of 17 materials were realized. NQP reference drug was developed and applied as accompanying control in whole-ingredient identification and primary grade evaluation of the samples. Results According to the results of 48 samples from 18 manufactures by primary grade evaluation, 10, 37, and 1 samples were classified as superior, qualified, and unqualified, respectively. Conclusion The proposed methods are accurate, simple, and objective, which offers a more comprehensive approach for quality control of NQP. And the methods provide research strategy and experimental basis for further work on establishment of grade standard.
