Secondary metabolites from endophytic fungus Fusarium oxysporum isolated from Paeonia ostii
10.7501/j.issn.0253-2670.2018.22.005
- Author:
Ju-Tao WANG
1
Author Information
1. Anhui Engineering Research Center of Modernized Chinese Material, School of Pharmacy, Anhui University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
(2S)- proline;
Cyclo-(S-Pro-S-Phe);
Endophytic fungus;
Fusarium oxysporum Schlecht.;
Paeonia ostii T. Hong et J. X. Zhang;
Secondary metabolites
- From:
Chinese Traditional and Herbal Drugs
2018;49(22):5247-5253
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the secondary metabolites of endophytic fungus Fusarium oxysporum form Paeonia ostii. Methods The fermentation liquor of the fungal strain F. oxysporum were isolated and purified using various chromatographic methods. The structures of the compounds were identified by spectrum analysis. Results Twenty-three compounds were isolated from the fungal and their structures were identified as (2S)-proline (1), (22E,24R)-ergosta-7,22-diene-3β,5α,6β-triol (2), cyclo-(S-Pro-S-Leu) (3), cyclo-(L-Ala-L-Pro) (4), cyclo-(Val-Pro) (5), cyclo-(R-Pro-S-Phe) (6), cyclo-(D-cis-Hyp-L-Phe) (7), cyclo-(trans-4-hydroxy- L-Pro-L-Phe) (8), cyclo-(Gla-Tyr) (9), cyclo-(trans-4-hydroxy-L-Pro-L-Leu) (10), L,L-cyclo-(Trp-Pro) (11), cyclo-(L-Leu-Gly) (12), N-(3-(1H-indol-3-yl)propyl)acetamide (13), indole-3-acetic acid (14), 2-piperidone (15), 2-pyrrolidinone (16), thymidine (17), (5S)-5-[(4-hydroxyphenyl)methyl]-2,4-imidazolidinedione (18), (3S,6S)-3-(butan-2-yl)-6-(1-hydroxyethyl) piperazine-2,5-dione (19), cyclo-(Ala-Leu) (20), cyclo-(S-Pro-S-Phe) (21), cyclo-(Tyr-Pro) (22), and cyclo-(L-Phe-L-Tyr) (23). Conclusion With the exception of compounds 2, 6, and 14, the other compounds are isolated from the fermentation liquor of the fungal strain F. oxysporum for the first time.