Historical story on natural medicinal chemistry: Statins, legend of best selling drugs
10.7501/j.issn.0253-2670.2018.23.001
- Author:
Qiao-Yue GAO
1
Author Information
1. College of Pharmaceutical Sciences, Hebei Medical University
- Publication Type:Journal Article
- Keywords:
Cardiovascular disease;
Cholesterol;
Drug development;
Microbial metabolites;
Statins
- From:
Chinese Traditional and Herbal Drugs
2018;49(23):5485-5495
- CountryChina
- Language:Chinese
-
Abstract:
Statins, a class of cholesterol-lowering drugs, have created a revolution in the prevention and treatment of cardiovascular disease. Mevastatin as the first statin originated from microbial metabolites. Its discovery is connected with the research of the biosynthesis of cholesterol. Atorvastatin, another statin, is one of the most famous blockbuster drugs in the pharmaceuticals market. The legend of statins is not only a success story in science, but also a classical case for business. In this paper, we review the research and development of statins and hope to give some enlightenment to scientists engaged in relevant research.
