Research progress on molecular mechanism of astragaloside IV in protecting kidney
10.7501/j.issn.0253-2670.2018.24.035
- Author:
Su-Zhi CHEN
1
Author Information
1. Tianjin University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Astragaloside IV;
Molecular mechanism;
Podocytes;
Renal fibrosis;
Renal tubular cell
- From:
Chinese Traditional and Herbal Drugs
2018;49(24):5973-5979
- CountryChina
- Language:Chinese
-
Abstract:
Astragaloside IV is the most aboundant and activitve ingredient in Astragalus membranaceus. Many studies have confirmed that astragaloside IV has a renal protective effect on chronic kidney disease. After reviewing the literatures at home and abroad for the past five years, The molecular mechanism of the protective effect of astragaloside IV on kidney was reviewed from the aspects of protection of podocytes, inhibition of renal fibrosis, protection of renal tubular cells, and inhibition of mesangial cell activation. The aim of this study is to analyze the target of astragaloside IV in the treatment of chronic kidney disease, and provide a basis for the application of astragaloside IV in nephropathy.
