Clinicopathologic Factors Affecting Recurrence after Curative Surgery for Stage I Colorectal Cancer.
10.3393/jksc.2012.28.1.49
- Author:
Min Ae KEUM
1
;
Seok Byung LIM
;
Sun A KIM
;
Yong Sik YOON
;
Chan Wook KIM
;
Chang Sik YU
;
Jin Cheon KIM
Author Information
1. Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. jckim@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Colorectal neoplasms;
Recurrence;
Risk factors
- MeSH:
Carcinoembryonic Antigen;
Colorectal Neoplasms;
Follow-Up Studies;
Humans;
Rectal Neoplasms;
Recurrence;
Retrospective Studies;
Risk Factors
- From:Journal of the Korean Society of Coloproctology
2012;28(1):49-55
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The objective of the current study was to identify the clinicopathological risk factors affecting recurrence after a curative resection for stage I colorectal cancer. METHODS: We retrospectively studied 434 patients who underwent a curative resection for stage I colorectal cancer between January 1999 and December 2004. Postoperative oral chemotherapy was performed in 189 patients (45.3%). The following prognostic factors were correlated with recurrence: age, gender, preoperative carcinoembryonic antigen level, location of tumor, T stage, size of tumor, histologic differentiation, growth pattern, and lymphovascular invasion. The median follow-up duration was 65 months. RESULTS: The overall recurrence rate was 4.6% (20/434). The median time to recurrence was 33 months. Two-thirds of the recurrence occurred more than two years after surgery. Risk factors associated with recurrence were rectal cancer (P = 0.009), T2 stage (P = 0.010), and infiltrative growth pattern (P = 0.020). A Cox proportional hazards regression analysis demonstrated that the infiltrative growth pattern was an independent predictor for recurrence. Tumor cell budding was observed in all pathologic reviews with recurrence. CONCLUSION: Long-term follow-up is necessary for stage I colorectal patients with high risk factors like rectal cancer, T2 stage, and infiltrative growth pattern.
