A new seco-triterpene from roots of Rosa laevifgata
10.7501/j.issn.0253-2670.2018.24.002
- Author:
Yi-Han LIU
1
Author Information
1. Tujia Medicine Research Center in Hunan, Jishou University
- Publication Type:Journal Article
- Keywords:
2α,3α- dihydroxyurs-12,18-dien-28-oic acid;
Anti-inflammatory activity;
Pomolic acid;
Roots of Rosa laevifgata;
Rosaceae;
Rosasecotriterpene A;
Triterpenes
- From:
Chinese Traditional and Herbal Drugs
2018;49(24):5740-5745
- CountryChina
- Language:Chinese
-
Abstract:
Objective Seven triterpenes were isolated from the methanol extract of the roots of Rosa laevifgata. Methods The compounds were isolated and purified by a combination of various chromatographic approaches, including silica gel, Sephadex LH-20, semipreparative HPLC and so on. Their structures were identified on the basis of pfysicochemiscal and spedtroscopic analysis. The in vitro anti-inflammatory activity test was investjgated. Results On the basis of spectroscopic data analysis, their structures were identified as 18,19-seco-2α,3β,23α-trihydoxyl-19-oxo-urs-11,13(18)-dien-28-oic acid (1), (2R,19R)-methyl 2-acetyloxy-19-hydroxyl-3-oxo-urs-12-en-28- oic acid (2), pomonic acid (3), cecropiacic acid 3-methyl ester (4), 2-acetyl tormentic acid (5), pomolic acid (6), and 2α,3α-dihydroxyurs-12,18-dien-28-oic acid (7). Conclusion Among them, compound 1 named as rosasecotriterpene A is a new triterpene. The anti-inflammatory activities of compounds 1—7 are tested in vitro. The results show that all the isolated compounds have obvious inhibitory effects on the release of NO from RAW264.7 cells induced by LPS. The inhibitory effects of compounds 1 and 7 are more significant, showing good anti-inflammatory activity in vitro.
