Difference of hypoglycemic and hypolipidemic effects of endangered species (Coptis deltoidea) and its processed products on T2DM rats
10.7501/j.issn.0253-2670.2019.01.020
- VernacularTitle: 濒危物种雅连及其不同炮制品对2型糖尿病大鼠的降糖调脂药效差异研究
- Author:
Rui-Ying LIU
1
Author Information
1. College of Life Science and Engineering, South-West Jiao Tong University
- Publication Type:Journal Article
- Keywords:
Coptis deltoidea C.Y. Cheng et Hsiao;
Diabetes;
Drug efficacy difference;
Endangered species;
Hypoglycemic;
Hypolipidemic;
Processed product
- From:
Chinese Traditional and Herbal Drugs
2019;50(1):129-133
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the difference of hypoglycemic and hypolipidemic effects of Coptis deltoidea (Coptis chinensis) and its processed products on T2DM rats. Methods Type 2 diabetes mellitus induced by high sugar, high fat diet and low dose of streptozotocin. C. deltoidea were processed with yellow wine, ginger, and evodia rutaecarpa, respectively. The effects of C. deltoidea on fasting blood glucose (FBG), fasting insulin (FINS), glycosylated serum protein (GSP), pancreatic pathology, serum triglyceride (TG), total cholesterol (TC) and lipoprotein (HDL-C or LDL-C) and key protein and gene expression of SCAP\SREBP-1c pathway in liver of model rats were investigated. Result C. deltoidea and its processed products reduced the FBG and GSP in T2DM rats. The wine products significantly reduced FBG and GSP in model rats (P < 0.01). The hypoglycemic range was better than raw and ginger products. At hypolipidemic aspect, C. deltoidea and its processed products decreased the content of TG, TC, and LDL-C (P < 0.05, 0.01), increased the content of HDL-C in serum (P < 0.05, 0.01), and down-regulated the protein and gene expression of SCAP/SREBP-1c in liver, the insulin target organ. However, wine and evodia products were better than crude drug or ginger products. Conclusion C. deltoidea processed by yellow wine, ginger and evodia rutaecarpa is traditional method to improve the disadvantages of C. deltoidea with bitter cold nature and not easy to take for a long time. However, different processing methods have different effects. Clinical medication should be combied withTCM syndrome differentiation and simple hypoglycemic effect of wine product is appropriate; while wine and evodia products were better in hypoglycemic and lipid regulation aspects.
