A new caffeoyl glucoside from Hedyotis caudatifolia with antitumor activity
10.7501/j.issn.0253-2670.2019.01.006
- VernacularTitle: 剑叶耳草中的1个新咖啡酸苷化学成分及其抗肿瘤活性
- Author:
Ming-Long CHEN
1
Author Information
1. College of Food Science and Biotechnology, Zhejiang Gongshang University
- Publication Type:Journal Article
- Keywords:
3α,19α-dihydroxyurs-12-en- 24,28-dioic acid;
Cytotoxicity;
Hedycaffeoylglucoside A;
Hedyotis caudatifolia Merr. et Metcalf;
Pomolic acid;
Rubiaceae
- From:
Chinese Traditional and Herbal Drugs
2019;50(1):25-29
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the chemical constituents of Hedyotis caudatifolia. Methods These compounds were isolated from H. caudatifolia and purified by repeated silica gel, polyamine, Sephadex LH-20 column chromatography and other methods. Their structures were identified by NMR, MS, and physico-chemical properties. Results Ten compounds were isolated and elucidated as hedycaffeoylglucoside A (1), β-sitosterol (2), 5α-stigmastane-3,6-dione (3), 7-hydroxy-6-methoxycoumarin (4), oleanolic acid (5), ursolic acid (6), pomolic acid (7), 3α,19α-dihydroxyurs-12-en-24,28-dioic acid (8), 2α,3β,24-trihydroxyolean-12-en-28-oic acid (9), and 2α,3α-dihydroxyolean-12-en-28-oic acid (10), respectively. Conclusion Compound 1 is a new caffeoyl glucoside and compounds 7-10 are isolated from this plant for the first time. Compound 1 exhibits cytotoxicity against four tumor cells.
