Effect and mechanism of natural compounds in treatment of EAE
10.7501/j.issn.0253-2670.2019.04.033
- Author:
Yuan-Hua WANG
1
Author Information
1. Institute of Clinical Immunology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Alkaloids;
Cytokine;
Experimental autoimmune encephalomyelitis;
Flavonoids;
Multiple sclerosis;
Polyphenols;
Signal pathway;
Terpenoids
- From:
Chinese Traditional and Herbal Drugs
2019;50(4):1012-1021
- CountryChina
- Language:Chinese
-
Abstract:
Experimental autoimmune encephalomyelitis (EAE) is a classic animal model for the study of human multiple sclerosis (MS). A number of studies have found that natural compounds possessed effects on the treatment of EAE. In this paper, we consulted related literatures, classified natural compounds such as alkaloids, flavonoids, terpenoids, and polyphenols, and explained the treatment mechanisms against EAE of Chinese materia medica, and to provide references for clinical research and treatment of neurological autoimmune diseases such as MS.
