Correlation between anticoagulant activity and ginsenoside content in six Panax species
10.7501/j.issn.0253-2670.2019.04.019
- Author:
Pan-Pan SHU
1
Author Information
1. School of Life Science and Technology, Kunming University of Science and Technology
- Publication Type:Journal Article
- Keywords:
Activated partial prothrombin time;
Correlation analysis;
Fenganticoagulant activity;
Fibrinogen;
Ginsenoside;
Panax ginseng C. A. Meyer;
Panax japlcus C. A. Mey. var. major (Burk.) C. Y. Wu et K. M Feng;
Panax japonicus C. A. Mey.;
Panax L.;
Panax notoginseng F. H. Chen;
Panax quinquefolius L.;
Panax stipuleanatus H. T. Tsai et K. M.;
Prothrombin time
- From:
Chinese Traditional and Herbal Drugs
2019;50(4):918-924
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the effects of different extracts from six Panax species on coagulation properties in vitro. Methods: The prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) assays were used to investigate the difference of anticoagulant activity of extracts and the correlation between anticoagulant activity and saponin content in six Panax species. Results: The results showed that Panax japonicus, P. japlcus, and P. notoginseng significantly prolonged PT and APTT, and reduced FIB content in a dose-dependent manner, while P. ginseng, P. quinquefolius, and P. stipuleanatus had no significant effects. Compared with the P. notoginseng group, the anticoagulant activity of the extracts of P. japonicus and P. japlcus was significantly stronger than that of P. notoginseng. Correlation analysis of ginsenoside content and anticoagulant activity showed that PT presented a positive correlation with ginsenoside Rb2 significantly. Ginsenoside Rb2 significantly prolonged PT and APTT. Conclusion :In summary, and anticoagulant activity is related to ginsenoside Rb2 content.
