Research progress on new drug delivery system of triptolide for anticancer therapy
10.7501/j.issn.0253-2670.2019.05.034
- Author:
Ji-Zheng SONG
1
Author Information
1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences
- Publication Type:Journal Article
- Keywords:
Antitumor activity;
Lipidosome;
Nanoparticle;
New drug delivery system;
Polymeric micelle;
Triptolide
- From:
Chinese Traditional and Herbal Drugs
2019;50(5):1269-1275
- CountryChina
- Language:Chinese
-
Abstract:
Triptolide had broad-spectrum and high-efficient anti-cancer activity, however, its clinical application was limited by the poor water solubility, in vivo rapid elimination, and strong toxicities and side effects. New drug delivery system was the ideal vehicle for targeted delivery of triptolide, which can effectively deliver triptolide to the cancer tissue, and increase the efficiency of tumor therapy. New drug delivery system had great application prospect in improving solubility of triptolide, reducing side effect, and increasing bioavailability. This article reviewed the research progress of new drug delivery system of triptolide based on liposome, polymer micelle and nanoparticle in the past decade, providing some references for the development and application of new drug delivery system of triptolide.
