A new benzophenone from endohydric moss Pogonatum inflexum
10.7501/j.issn.0253-2670.2019.06.003
- Author:
Xu-Hong DUAN
1
Author Information
1. College of Life Science, Hebei Normal University
- Publication Type:Journal Article
- Keywords:
2-(4-benzoyl-3- hydroxyphenoxy)-1-(piperidin-1-yl) ethan-1-one;
Benzophenones;
Cytotoxic activity;
Pogonatone A;
Pogonatum inflexum (Lindb.) Lac.;
Polytrichaceae
- From:
Chinese Traditional and Herbal Drugs
2019;50(6):1291-1293
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical components of endohydric moss Pogonatum inflexum in order to find new bioactive compounds. Methods The constituents were separated by column chromatographic methods of silica gel, MCI-Gel resin, Sephadex LH-20, and HPLC. The structures were elucidated by spectroscopic data analysis. The cytotoxicity of compounds for HepG2, HL-60, A549, and MCF7 cell line was also evaluated by using MTT method. Results Two compounds were isolated and identified as 2-(4-benzoyl-3-hydroxyphenoxy)-1-(piperidin-1-yl) ethan-1-one (1) and tert-butyl-2-(4-benzoyl-3-hydroxyphenoxy) acetate (2). Conclusion Compounds 1 is a new compound named pogonatone A; Compound 2 is isolated from Polytrichaceae species for the first time; Compound 1 also displays the high cytotoxicity to HepG2 cell line.
